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Preparation and evaluation of film forming polymeric dispersion containing Centella asiatica extract for skin application

Oriental Pharmacy and Experimental Medicine 2021년 21권 1호 p.73 ~ 81
Monton Chaowalit, Luprasong Chitradee, Suksaeree Jirapornchai, Songsak Thanapat,
소속 상세정보
 ( Monton Chaowalit ) - Rangsit University College of Pharmacy
 ( Luprasong Chitradee ) - Rangsit University College of Pharmacy
 ( Suksaeree Jirapornchai ) - Rangsit University College of Pharmacy Department of Pharmaceutical Chemistry
 ( Songsak Thanapat ) - Rangsit University College of Pharmacy Department of Pharmacognosy

Abstract


The aim of this work was to develop the film forming polymeric dispersion (FFPD) containing Centella asiatica extract for topical use. Eudragit® RS 30D and Eudragit® RL 30D were used as the film forming agents. Glycerin was used as a plasticizer. Ethanol was used as penetration enhancer and for shortening of film drying time. The best FFPD formulation contained Eudragit® RL 30D 50%, glycerin 20%, ethanol 20%, and C. asiatica extract 10%. It formed a complete film within 10?15 min after application to the skin. The low content of madecassoside and asiaticoside was released from FFPD. Approximately 5% of madecassoside and 6% of asiaticoside were accumulated in the skin within 12 h of skin permeation test. FFPD was stable for more than 60 days but less than 90 days. Nevertheless, formulations will be developed in our future work to improve the stability and increase the skin permeation of the formulation.

키워드

Centella asiatica; Film forming polymeric dispersion; Asiaticoside; Madecassoside; Skin application

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