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Quercetin attenuates the reduction of parvalbumin in middle cerebral artery occlusion animal model

Laboratory Animal Research 2021년 37권 1호 p.9 ~ 9
박동주, 강주빈, Shah Fawad-Ali, 고필옥,
소속 상세정보
박동주 ( Park Dong-Ju ) - Gyeongsang National University College of Veterinary Medicine Department of Anatomy
강주빈 ( Kang Ju-Bin ) - Gyeongsang National University College of Veterinary Medicine Department of Anatomy
 ( Shah Fawad-Ali ) - Gyeongsang National University College of Veterinary Medicine Department of Anatomy
고필옥 ( Koh Phil-Ok ) - Gyeongsang National University College of Veterinary Medicine Department of Anatomy

Abstract


Background: Calcium is a critical factor involved in modulation of essential cellular functions. Parvalbumin is a calcium buffering protein that regulates intracellular calcium concentrations. It prevents rises in calcium concentrations and inhibits apoptotic processes during ischemic injury. Quercetin exerts potent antioxidant and anti-apoptotic effects during brain ischemia. We investigated whether quercetin can regulate parvalbumin expression in cerebral ischemia and glutamate toxicity-induced neuronal cell death. Adult male rats were treated with vehicle or quercetin (10 mg/kg) 30 min prior to middle cerebral artery occlusion (MCAO) and cerebral cortical tissues were collected 24 h after MCAO. We used various techniques including Western blot, reverse transcription-PCR, and immunohistochemical staining to elucidate the changes of parvalbumin expression.

Results: Quercetin ameliorated MCAO-induced neurological deficits and behavioral changes. Moreover, quercetin prevented MCAO-induced a decrease in parvalbumin expression.

Conclusions: These findings suggest that quercetin exerts a neuroprotective effect through regulation of parvalbumin expression.

키워드

Cerebral ischemia; Neuroprotection; Parvalbumin; Quercetin

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