잠시만 기다려 주세요. 로딩중입니다.

Dysregulated Dermal Mesenchymal Stem Cell Proliferation and Differentiation Interfered by Glucose Metabolism in Psoriasis

International Journal of Stem Cells 2021년 14권 1호 p.85 ~ 93
Zhao Xincheng, Xing Jianxiao, Li Junqin, Hou Ruixia, Niu Xuping, Liu Ruifeng, Jiao Juanjuan, Yang Xiaohong, Li Juan, Liang Jiannan, Zhou Ling, Wang Qiang, Chang Wenjuan, Yin Guohua, Li Xinhua, Zhang Kaiming,
소속 상세정보
 ( Zhao Xincheng ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Xing Jianxiao ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Li Junqin ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Hou Ruixia ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Niu Xuping ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Liu Ruifeng ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Jiao Juanjuan ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Yang Xiaohong ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Li Juan ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Liang Jiannan ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Zhou Ling ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Wang Qiang ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Chang Wenjuan ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Yin Guohua ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Li Xinhua ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology
 ( Zhang Kaiming ) - Shanxi Medical University Taiyuan City Centre Hospital Institute of Dermatology

Abstract


Background and Objectives: Psoriasis is a chronic inflammatory skin disease, which the mechanisms behind its initiation and development are related to many factors. DMSCs (dermal mesenchymal stem cells) represent an important member of the skin microenvironment and play an important role in the surrounding environment and in neighbouring cells, but they are also affected by the microenvironment. We studied the glucose metabolism of DMSCs in psoriasis patients and a control group to reveal the relationship among glucose metabolism, cell proliferation activity,and VEC (vascular endothelial cell) differentiation in vitro, we demonstrated the biological activity and molecular mechanisms of DMSCs in psoriasis.

Methods and Results: We found that the OCR of DMSCs in psoriatic lesions was higher than that in the control group, and mRNA of GLUT1 and HK2 were up-regulated compared with the control group. The proliferative activity of DMSCs in psoriasis was reduced at an early stage, and mRNA involved in proliferation, JUNB and FOS were expressed at lower levels than those in the control group. The number of blood vessels in psoriatic lesions was significantly higher than that in the control group (p<0.05), which the mRNA of VEC differentiation, CXCL12, CXCR7, HEYL and RGS5 tended to be increased in psoriatic lesions compared to the control group, in addition to Notch3.

Conclusions: We speculated that DMSCs affected local psoriatic blood vessels through glucose metabolism, and the differentiation of VECs, which resulted in the pathophysiological process of psoriasis.

키워드

Cell proliferation; DMSCs; Glucose metabolism; Psoriasis; Vascular differention

원문 및 링크아웃 정보

등재저널 정보