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Important Role of Immunological Responses to Environmental Exposure in the Development of Allergic Asthma

Allergy, Asthma & Immunology Research : AAIR 2020년 12권 6호 p.934 ~ 948
Lin Xinliu, Ren Xia, Xiao Xiaojun, Yang Zhaowei, Yao Siyang, Wong Gary W. K., Liu Zhigang, Wang Charles, Su Zhong, Li Jing,
소속 상세정보
 ( Lin Xinliu ) - Guangzhou Medical University First Affiliated Hospital Department of Allergy and Clinical Immunology
 ( Ren Xia ) - Guangzhou Medical University First Affiliated Hospital Department of Allergy and Clinical Immunology
 ( Xiao Xiaojun ) - Shenzhen University School of Medicine Institute of Allergy and Immunology
 ( Yang Zhaowei ) - Guangzhou Medical University First Affiliated Hospital Department of Allergy and Clinical Immunology
 ( Yao Siyang ) - Guangzhou Medical University First Affiliated Hospital Department of Allergy and Clinical Immunology
 ( Wong Gary W. K. ) - Chinese University of Hong Kong Prince of Wales Hospital Departments of Pediatrics
 ( Liu Zhigang ) - Shenzhen University School of Medicine Institute of Allergy and Immunology
 ( Wang Charles ) - Guangzhou Medical University First Affiliated Hospital Department of Allergy and Clinical Immunology
 ( Su Zhong ) - Chinese Academy of Sciences Guangzhou Institute of Biomedicine and Health
 ( Li Jing ) - Guangzhou Medical University First Affiliated Hospital Department of Allergy and Clinical Immunology

Abstract


Allergic asthma is a public health problem that affects human health and socioeconomic development. Studies have found that the prevalence of asthma has significantly increased in recent years, which has become particularly pronounced in developed countries. With rapid urbanization in China in the last 3 decades, the prevalence of asthma has increased significantly in urban areas. As changes in genetic backgrounds of human populations are limited, environmental exposure may be a major factor that is responsible for the increased prevalence of asthma. This review focuses on environmental components of farms and rural areas that may have protective effects in reducing the development of asthma. Farm and rural related microorganism- and pathogen-associated molecular patterns are considered to be important environmental factors that modulate host's innate and adaptive immune system to induce protection effects later in life. Environmental microbial-related immunotherapy will also be discussed as the future research direction for the prevention of allergic asthma.

키워드

Asthma; epidemiology; hygiene hypothesis; environmental exposure; house dust mite

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