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A Potential Role of Group 2 Innate Lymphoid Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, Asthma & Immunology Research : AAIR 2021년 13권 3호 p.363 ~ 374
Li Yan, Wang Wei, Ying Sun, Lan Feng, Zhang Luo,
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 ( Li Yan ) - Capital Medical University Beijing Tongren Hospital Department of Otorhinolaryngology Head and Neck Surgery
 ( Wang Wei ) - Capital Medical University School of Basic Medical Sciences Department of Immunology
 ( Ying Sun ) - Capital Medical University School of Basic Medical Sciences Department of Immunology
 ( Lan Feng ) - Capital Medical University Beijing Tongren Hospital Department of Otorhinolaryngology Head and Neck Surgery
 ( Zhang Luo ) - Capital Medical University Beijing Tongren Hospital Department of Otorhinolaryngology Head and Neck Surgery

Abstract


Chronic rhinosinusitis with nasal polyps (CRSwNP), a type 2-based upper airway disease, is mainly characterized by high asthma comorbidity and recurrence after surgery. It has been shown that type 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13 released from T helper 2 (Th2) cells as well as group 2 innate lymphoid cells (ILC2s), contribute to chronic inflammation of CRSwNP. This review summarizes recent progresses made in our understanding of ILC2 activity, particularly ILC2 accumulation at airway inflammation sites, cooperation with Th2 cells in aggravating the CRSwNP inflammatory process and interactions with regulatory T cells (Tregs) in resisting Tregs-mediated suppressive function in allergic inflammation. A better understanding of the biology of ILC2s should lay a good foundation in elucidating the pathogenesis of CRSwNP, and subsequently may lead to the development of new therapeutic strategies for the management of CRSwNP.

키워드

Sinusitis; nasal polyps; innate immunity; lymphocytes; Treg cells; eosinophils; respiratory tract diseases; asthmas; cytokines

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