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Interactions Between IL-17 Variants and Streptococcus in the Gut Contribute to the Development of Atopic Dermatitis in Infancy

Allergy, Asthma & Immunology Research : AAIR 2021년 13권 3호 p.404 ~ 419
강미진, 이소연, 박윤미, 김봉수, 이민정, 김정현, 정선미, 이승화, 박민지, Rhee Eun-Sang, 정성수, 윤지선, 조현주, 이은, 양송이, 서동인, 김경원, 신윤호, 안강모, 홍수종,
소속 상세정보
강미진 ( Kang Mi-Jin ) - Asan Medical Center Humidifier Disinfectant Health Center
이소연 ( Lee So-Yeon ) - University of Ulsan College of Medicine Asan Medical Center Department of Pediatrics
박윤미 ( Park Yoon-Mee ) - Asan Medical Center Asan Institute for Life Sciences
김봉수 ( Kim Bong-Soo ) - Hallym University Department of Life Sciences
이민정 ( Lee Min-Jung ) - Hallym University Department of Life Sciences
김정현 ( Kim Jeong-Hyun ) - University of Ulsan College of Medicine Department of Medicine
정선미 ( Jeong Seon-Mi ) - University of Ulsan College of Medicine Asan Medical Center Asan Institute for Life Sciences
이승화 ( Lee Seung-Hwa ) - University of Ulsan College of Medicine Asan Medical Center Asan Institute for Life Sciences
박민지 ( Park Min-Jee ) - University of Ulsan College of Medicine Asan Medical Center Department of Pediatrics
 ( Rhee Eun-Sang ) - University of Ulsan College of Medicine Asan Medical Center Department of Pediatrics
정성수 ( Jung Sung-Su ) - Pusan National University Yangsan Hospital Department of Pediatrics
윤지선 ( Yoon Ji-Sun ) - Mediplex Sejong Hospital Department of Pediatrics
조현주 ( Cho Hyun-Ju ) - Catholic Kwandong University College of Medicine International St. Mary’s Hospital Department of Pediatrics
이은 ( Lee Eun ) - Chonnam National University Medical School Chonnam National University Hospital Department of Pediatrics
양송이 ( Yang Song-I ) - Hallym University College of Medicine Hallym University Sacred Heart Hospital Department of Pediatrics
서동인 ( Suh Dong-In ) - Seoul National University College of Medicine Department of Pediatrics
김경원 ( Kim Kyung-Won ) - Yonsei University College of Medicine Department of Pediatrics
신윤호 ( Sheen Youn-Ho ) - CHA University School of Medicine CHA Gangnam Medical Center Department of Pediatrics
안강모 ( Ahn Kang-Mo ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Pediatrics
홍수종 ( Hong Soo-Jong ) - University of Ulsan College of Medicine Asan Medical Center Department of Pediatrics

Abstract


Purpose: Interleukin (IL)-17 variants and perturbations in the gut microbiota may influence the development of atopic dermatitis (AD). However, unifying principles for variants of host and microbe interaction remains unclear. We sought to investigate whether IL-17 variants and gut microbiota affect the development of AD in infancy.

Methods: Composition of the gut microbiota was analyzed in fecal samples from 99 normal healthy and 61 AD infants at 6 months of age. The associations between total immunoglobulin E (IgE), the scoring atopic dermatitis (SCORAD), short-chain fatty acids, transcriptome and functional profile of the gut measured in these subjects and Streptococcus were analyzed. IL-6 and IL-8 in the human intestinal epithelial cell line (HIEC-6) were measured after stimulation of IL-17 and Streptococcus mitis.

Results: In this study, Streptococcus was enriched in infants with AD and was higher in those with the GA + AA of IL-17 (rs2275913) variant. Streptococcus was positively correlated with IgE and SCORAD in infants with AD and GA + AA of IL-17. Butyrate and valerate were negatively correlated with Streptococcus and were decreased in infants with AD and GA + AA. Bacterial genes for oxidative phosphorylation induced by reduced colonization of Clostridium were decreased compared with normal and GG. In transcriptome analysis, lactate dehydrogenase A-like 6B was higher in infants with AD compared with healthy infants. IL-6 and IL-8 were increased in IL-17 and/or S. mitis-stimulated HIEC-6 cells.

Conclusions: These findings suggest that increased Streptococcus and A allele of IL-17 (rs2275913) may contribute to the pathogenesis of AD via modulation of the immune system in infancy.

키워드

Atopic dermatitis; gastrointestinal microbiome; Streptococcus; IL-17

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