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Effect of Korean Red Ginseng on Early Vestibular Function Restoration after Unilateral Labyrinthectomy

Research in Vestibular Science 2020년 19권 3호 p.79 ~ 88
이지연, 김미주, 한규철,
소속 상세정보
이지연 ( Lee Ji-Yeon ) - Catholic Kwandong University International St. Mary’s Hospital Department of Otorhinolaryngology-Head and Neck Surgery
김미주 ( Kim Mi-Joo ) - Catholic Kwandong University International St. Mary’s Hospital Department of Otorhinolaryngology-Head and Neck Surgery
한규철 ( Han Gyu-Cheol ) - Gachon University School of Medicine Department of Otolaryngology-Head and Neck Surgery

Abstract


Objectives: Vertigo is a common condition. Definitive treatment is to induce vestibular compensation. Currently, no medications have been discovered that enhance vestibular functional restoration. The current study was conducted to evaluate the ability of ordinary Korean red ginseng (KRG) to induce vestibular compensation.

Method: Twelve Sprague-Dawley rats were divided into two groups. Five rats (KRG group) were fed KRG extract (100 mg/kg) for 2 weeks before undergoing unilateral labyrinthectomy (ULx). The remaining seven rats (control group) were untreated before ULx. After surgery, all animals were housed in the same environment without being fed additional extract. To evaluate vestibular function, gain of the horizontal nystagmus to 0.2 Hz with a peak velocity of 100°/second sinusoidal rotation was compared and analyzed before ULx as well as 3 and 7 days after surgery.

Results: Before the operation, gain of the control and KRG group were 0.81±0.05 and 0.88±0.08, respectively, with 0.2-Hz stimulation. This value decreased to 0.43±0.08 and 0.53±0.08, respectively on 3 days after operation (p=0.047), and it was 0.40±0.06 and 0.68±0.11, respectively on 7 days after surgery. The difference of gain between the two groups was statistically significant at each 3 and 7 days (p<0.05). By confirming c-Fos protein expression in medial vestibular nuclei, the functional effect of KRG causing vestibular modulation was confirmed.

Conclusions: Rats treated with KRG showed more rapid and complete recovery after acute vestibular loss compared to untreated animals. Therefore, KRG could be one of candidate for the useful medication of vestibular diseases.

키워드

Compensation; Ginseng; Vertigo; Vestibule

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