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Intravenous Zoledronic Acid in Elderly Patients with Benign Paroxysmal Positional Vertigo and Osteoporosis

Research in Vestibular Science 2020년 19권 3호 p.95 ~ 98
곽동원, 이혜미, 김동욱,
소속 상세정보
곽동원 ( Kwack Dong-Won ) - Konkuk University School of Medicine Department of Neurology
이혜미 ( Lee Hye-Mi ) - Konkuk University School of Medicine Department of Neurology
김동욱 ( Kim Dong-Wook ) - Konkuk University School of Medicine Department of Neurology

Abstract


Objectives: Benign paroxysmal positional vertigo (BPPV), a common cause of vertigo in the elderly, shares common pathogenic mechanisms with osteoporosis. We investigated the efficacy and safety of intravenous zoledronic acid in elderly patients with BPPV and osteoporosis.

Method: We performed a 3-year observational study with elderly patients who were diagnosed with BPPV and osteoporosis. The recurrence of BPPV and changes in bone mineral densitometry (BMD) scores were evaluated one year after the administration of intravenous zoledronic acid.

Results: We enrolled 101 elderly patients with BPPV and 54 of them (53.5%) met the diagnostic criteria for osteoporosis. Intravenous zoledronic acid was administered in 51 patients. The recurrence of BPPV was observed in only two of 49 patients (4.1%) at 1 year’s follow-up. The mean lowest T-score of BMD improved from ?3.23±0.51 to ?3.05±0.58 (p=0.001).

Conclusions: Our study showed that the treatment of osteoporosis can be considered to prevent the recurrence of BPPV in the elderly. Further placebo-controlled studies are needed to estimate accurately the efficacy of zoledronic acid in the prevention of recurrence of BPPV in the elderly.

키워드

Benign paroxysmal positional vertigo; Vertigo; Aged; Zoledronic acid

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