잠시만 기다려 주세요. 로딩중입니다.

Stem Cell Therapy for Neurogenic Bladder Dysfunction in Rodent Models: A Systematic Review

International Neurourology Journal 2020년 24권 3호 p.241 ~ 257
Salehi-Pourmehr Hanieh, Hajebrahimi Sakineh, Rahbarghazi Reza, Pashazadeh Fariba, Mahmoudi Javad, Maasoumi Narjes, Sadigh-Eteghad Saeed,
소속 상세정보
 ( Salehi-Pourmehr Hanieh ) - Tabriz University of Medical Sciences Research Center for Evidence-Based Medicine
 ( Hajebrahimi Sakineh ) - Tabriz University of Medical Sciences Research Center for Evidence-Based Medicine
 ( Rahbarghazi Reza ) - Tabriz University of Medical Sciences Stem Cell Research Center
 ( Pashazadeh Fariba ) - Tabriz University of Medical Sciences Research Center for Evidence-Based Medicine
 ( Mahmoudi Javad ) - Tabriz University of Medical Sciences Neurosciences Research Center
 ( Maasoumi Narjes ) - University Hospital Southampton
 ( Sadigh-Eteghad Saeed ) - Tabriz University of Medical Sciences Neurosciences Research Center

Abstract


Purpose: Neurogenic bladder dysfunction (NGB) has an impact on the quality of life, which made it an important research subject in preclinical studies. The present review investigates the effect of stem cell (SC) therapy on bladder functional recovery after the onset of spinal cord injury (SCI), multiple sclerosis (MS), Parkinson disease (PD), and stroke in rodent models.

Methods: All experiments evaluated the regenerative potential of SC on the management of NGB in rodent models up to June 2019, were included. From 1,189 relevant publications, 20 studies met our inclusion criteria of which 15 were conducted on SCI, 2 on PD, 2 on stroke, and 1 on MS in the rodent models. We conducted a meta-analysis on SCI experiments and for other neurological diseases, detailed urodynamic findings were reported.

Results: The common SC sources used for therapeutical purposes were neural progenitor cells, bone marrow mesenchymal SCs, human amniotic fluid SCs, and human umbilical cord blood SCs. There was a significant improvement of micturition pressure in both contusion and transaction SCI models 4 and 8 weeks post-SC transplantation. Residual urine volume, micturition volume, and bladder capacity were improved 28 days after SC transplantation only in the transaction model of SCI. Nonvoiding contraction recovered only in 56 days post-cell transplantation in the contusion model.

Conclusions: Partial bladder recovery has been evident after SC therapy in SCI models. Due to limitations in the number of studies in other neurological diseases, additional studies are necessary to confirm the detailed mechanism for bladder recovery.

키워드

Stem cell therapy; Neurogenic bladder; Rodent models; Systematic review

원문 및 링크아웃 정보

 

등재저널 정보