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Seasonal Variation of Drug Prescription Rate for Overactive Bladder in Men Based on National Health Insurance Claims Data, 2012?2016

International Neurourology Journal 2020년 24권 3호 p.278 ~ 285
김종원, 안현규, 고종철, Lee Dongu, Ha Jee-Soo, 김재환, 박소정, 조강수,
소속 상세정보
김종원 ( Kim Jong-Won ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Urology
안현규 ( Ahn Hyun-Kyu ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Urology
고종철 ( Ko Jong-Cheol ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Urology
 ( Lee Dongu ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Urology
 ( Ha Jee-Soo ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Urology
김재환 ( Kim Jae-Hwan ) - Hanmi Pharmaceutical. Co. Ltd. Data Science Team
박소정 ( Park So-Jeong ) - Hanmi Pharmaceutical. Co. Ltd. Data Science Team
조강수 ( Cho Kang-Su ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Urology

Abstract


Purpose: Overactive bladder (OAB) symptoms might be affected by weather, but only a few clinical studies have investigated this issue. We investigated seasonal variations in OAB-drug prescription rate (DPR) in men using nationwide claims data in Korea.

Methods: A total of 2,824,140 men aged over 18 years were included from the Health Insurance Review and Assessment service ? National Patient Sample data between 2012 and 2016. Depending on the monthly average temperature, the seasons were divided into 3 groups, namely, hot (June, July, August, and September), intermediate (April, May, October, and November), and cold (January, February, March, and December) seasons. OAB-DPR was estimated using the claims data, and differences in its rate were examined among the 3 seasonal groups.

Results: The overall OAB-DPR was 1.97% (55,574 of 2,824,140). The OAB-DPR were 0.38%, 0.63%, 0.92%, 1.74%, 4.18%, 7.55%, and 9.69% in the age groups of under 30, 30s, 40s, 50s, 60s, 70s, and over 80 years, respectively; thus, the prescription rate increased with age (P<0.001), with a steeper increase after 60 years of age. OAB-DPR was 1.02% in the hot season, 1.19% in the intermediate season, and 1.27% in the cold season, with significant differences among the 3 seasonal groups (P<0.001). These seasonal variations persisted in the subgroup analysis in each age decade (P<0.001).

Conclusions: OAB-DPR varied with seasons and was significantly higher in the cold season than in the hot season, suggesting that cold weather may affect development and aggravation of OAB symptoms in men.

키워드

Men; Seasons; Urinary bladder, Overactive

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