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Application of Polarization Sensitive-Optical Coherence Tomography to the Assessment of Phase Retardation in Subpleural Cancer in Rabbits

Tissue Engineering and Regenerative Medicine 2021년 18권 1호 p.61 ~ 69
박정은, Xin Zhou, 권다영, 김성원, 이해영, 정민정, Tang Shuo, 고택용, 최진혁, 김준형, 안예찬, 옥철호,
소속 상세정보
박정은 ( Park Jung-Eun ) - Pukyong National University Department of Biomedical Engineering
 ( Xin Zhou ) - University of British Columbia Department of Electrical and Computer Engineering
권다영 ( Kwon Daa-Young ) - Pukyong National University Department of Biomedical Engineering
김성원 ( Kim Sung-Won ) - Kosin University College of Medicine Department of Otolaryngology-Head and Neck Surgery
이해영 ( Lee Hae-Young ) - Kosin University College of Medicine Department of Thoracic and Cardiovascular Surgery
정민정 ( Jung Min-Jung ) - Kosin University College of Medicine Department of Pathology
 ( Tang Shuo ) - University of British Columbia Department of Electrical and Computer Engineering
고택용 ( Ko Taek-Yong ) - Kosin University College of Medicine Department of Thoracic and Cardiovascular Surgery
최진혁 ( Choi Jin-Hyuk ) - Kosin University College of Medicine Department of Surgery
김준형 ( Kim Jun-Hyeong ) - Kosin University College of Medicine Department of Internal Medicine
안예찬 ( Ahn Yeh-Chan ) - Pukyong National University Department of Biomedical Engineering
옥철호 ( Oak Chul-Ho ) - Kosin University College of Medicine Department of Internal Medicine

Abstract


Background: Polarization sensitive-optical coherence tomography (PS-OCT) provides the unique advantage of being able to measure the optical characteristics of tissues by using polarized light. Although the well-organized fibers of healthy muscle can change the polarization states of passing light, damaged tissue has different behaviors. There are studies on optical imaging methods applied to the respiratory organs; however, they are restricted to structural imaging. In particular, the intercostal muscle situated under the pleura is very challenging to visualize due to the difficulty of access.

Method: In this study, PS-OCT was used to identify subpleural cancer in male New Zealand white rabbits (3.2?3.4 kg) and to assess the phase retardation changes in normal and cancerous chest walls. VX2 cell suspension was injected between the intercostal muscle and parietal pleura and a tented area was observed by thoracic scope. A group of rabbits (n?=?3) were sacrificed at day 7 after injection and another group (n?=?3) at day 14.

Results: In the PS-OCT images, pleura thickness changes and muscle damage were criteria to understand the stages of the disease. The results of image and phase retardation analysis matched well with the pathologic examinations.

Conclusion: We were able to visualize and analyze subpleural cancer by PS-OCT, which provided structural and functional information. The measured phase retardation could help to identify the margin of the tumor. For further studies, various approaches into other diseases using polarization light are expected to have positive results.

키워드

Subpleural cancer; Polarization sensitive; Optical coherence tomography

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