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Intra-articular Injection of Chitosan-Based Supramolecular Hydrogel for Osteoarthritis Treatment

Tissue Engineering and Regenerative Medicine 2021년 18권 1호 p.113 ~ 125
Mou Donggang, Yu Qunying, Zhang Jimei, Zhou Jianping, Li Xinmin, Zhuang Weiyi, Yang Xuming,
소속 상세정보
 ( Mou Donggang ) - Kunming Medical University Yan’an Hospital Department of Orthopedics
 ( Yu Qunying ) - Kunming Medical University Second Affiliated Hospital Department of Maternity
 ( Zhang Jimei ) - Kunming Medical University Yan’an Hospital Chenggong Hospital Department of Gastroenterology
 ( Zhou Jianping ) - Kunming Medical University Yan’an Hospital Chenggong Hospital Department of Orthopedics
 ( Li Xinmin ) - Kunming Medical University Yan’an Hospital Chenggong Hospital Department of Orthopedics
 ( Zhuang Weiyi ) - Kunming Medical University Yan’an Hospital Chenggong Hospital Department of Cardiology
 ( Yang Xuming ) - Kunming Medical University Yan’an Hospital Chenggong Hospital Department of Orthopedics

Abstract


Background: Pain and cartilage destruction caused by osteoarthritis (OA) is a major challenge in clinical treatment. Traditional intra-articular injection of hyaluronic acid (HA) can relieve the disease, but limited by the difficulty of long-term maintenance of efficacy.

Methods: In this study, an injectable and self-healing hydrogel was synthesized by in situ crosslinking of N-carboxyethyl chitosan (N-chitosan), adipic acid dihydrazide (ADH), and hyaluronic acid?aldehyde (HA-ALD).

Results: This supramolecular hydrogel sustains good biocompatibility for chondrocytes. Intra-articular injection of this novel hydrogel can significantly alleviate the local inflammation microenvironment in knee joints, through inhibiting the inflammatory cytokines (such as TNF-α, IL-1β, IL-6 and IL-17) in the synovial fluid and cartilage at 2- and even 12-weeks post-injection. Histological and behavioral test indicated that hydrogel injection protected cartilage destruction and relieved pain in OA rats, in comparison to HA injection.

Conclusion: This kind of novel hydrogel, which is superior to the traditional HA injection, reveals a great potential for the treatment of OA.

키워드

Chitosan; Hyaluronic acid; Hydrogel; Osteoarthritis; Intra-articular injection

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